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A novel improved synthesis of 3‐aminopyrazine‐2‐carboxylic acid
Author(s) -
Buckland Paul R.
Publication year - 1980
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570170238
Subject(s) - chemistry , yield (engineering) , pyrazine , amide , carboxylic acid , salt (chemistry) , ammonium , dicarboxylic acid , organic chemistry , metallurgy , materials science
A three step synthesis of 3‐aminopyrazine‐2‐carboxylic acid ( 1 ) starting from pyrazine‐2,3‐dicarboxylic acid ( 5 ) is described. Diacid 5 is converted via the anhydride 6 into the ammonium salt of the half acid amide 7 which on Hofmann rearrangement gives the title compound in 55% overall yield.
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