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Studies on chemotherapeutics I. Synthesis of 5‐substituted‐4‐oxo‐1,4‐dihydro‐3‐pyridinecarboxylic acid derivatives
Author(s) -
Balogh MÁRia,
Hermecz István,
Mészaros Zoltán,
Simon KÁLman,
Pusztay Levente,
Horváth GÁBor,
Dvortsak Peter
Publication year - 1980
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570170229
Subject(s) - chemistry , sodium ethoxide , ethyl acetoacetate , alkyl , ethanol , hydrolysis , alkylation , halide , alkaline hydrolysis , antimicrobial , organic chemistry , medicinal chemistry , catalysis
Ethyl 5‐substituted‐4‐oxo‐1,4‐dihydro‐3‐pyridinecarboxylates were synthetized by reacting 1,3,5‐triazine with 4‐substituted ethyl acetoacetate derivatives in ethanol, in the presence of sodium ethoxide. The l‐alkyl‐5‐substituted‐4‐oxo‐1,4‐dihydro‐3‐pyridinecarboxylic acids required for the antimicrobial studies were prepared by N ‐alkylation (with triethyl phosphate or alkyl halides) and alkaline hydrolysis of the pyridone esters.