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New heterocyclic ring systems. XII. Synthesis of [1,4]thiazinocarbazoles
Author(s) -
Brunelli C.,
Fravolini A.,
Grandolini G.,
Strappaghetti G.
Publication year - 1980
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570170140
Subject(s) - chemistry , ring (chemistry) , stereochemistry , spectral properties , combinatorial chemistry , medicinal chemistry , organic chemistry , computational chemistry
Five [1,4]thiazinocarbazoles have been synthesized from 6‐, 7‐ and 8‐amino‐2 H [1,4]benzo‐thiazin‐3(4 H )ones by the Jaap‐Klingemann reaction with 2‐hydroxymethylenecyclohexanone followed by Fischer indolisation of the resulting hydrazones. The structures of the hitherto unknown ring systems have been confirmed by pmr spectral data.