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Thiohydrazides and acetylene esters, A new route to 1,3,4‐thiadiazoles
Author(s) -
Heindel Ned D.,
Friedrich Gail,
Tsai Maria C.
Publication year - 1980
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570170138
Subject(s) - chemistry , thiadiazoles , dimethyl acetylenedicarboxylate , yield (engineering) , acetylene , methyl acrylate , organic chemistry , medicinal chemistry , catalysis , copolymer , cycloaddition , materials science , polymer , metallurgy
Aromatic thiohydrazides react with dimethyl acetylenedicarboxylate or methyl propiolate to yield carbomethoxymethyl‐substituted 1,3,4‐thiadiazoles. In a 2:1 ratio of methyl propiolate to aromatic thiohydrazide, 1,3,4‐thiadiazoles with acrylate ester side chains are formed.