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Alkylating nucleosides. 3 . The reaction of 3,5‐dimethylpyrazole nucleosides with N ‐bromosuccinimide
Author(s) -
Garcia Lópe M. Teresa,
Herranz Rosario,
Alonso Gregorio
Publication year - 1980
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570170123
Subject(s) - chemistry , n bromosuccinimide , halogenation , hela , pyrazole , stereochemistry , medicinal chemistry , organic chemistry , cell , biochemistry
Abstract Bromination of 3,5‐dimethylpyrazole nucleosides with N ‐bromosuccinimide gave the corresponding 4‐bromo‐3,5‐dimethylpyrazole, 3‐methyl‐5‐(bromomethyl)pyrazole and 4‐bromo‐3‐methyl‐5‐(bromomethyl)pyrazole nucleosides. Structural assignments were made on basis of analytical and 1 H nmr spectral data. All of the bromomethylpyrazole nucleosides described showed cytostatic activity against HeLa cell sultures.