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2‐Imidazolines. III (1). 1‐Aryl‐ and 1‐acyl‐2‐amino‐(ormethoxy)‐4,5‐diamino‐4,5‐dihydroimidazoles. Synthesis and properties
Author(s) -
Citerio Luisa,
Rivera Elisabetta,
Saccarello Maria Luisa,
Stradi Riccardo,
Gioia Bruno
Publication year - 1980
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570170120
Subject(s) - chemistry , aryl , pyrimidine , amino acid , salt (chemistry) , ring (chemistry) , medicinal chemistry , stereochemistry , organic chemistry , biochemistry , alkyl
Abstract Diimmonium salt (5) reacts with guanidines (6) and o ‐methylisoureas (7) affording 2‐amino‐4,5‐dimorpholinoimidazolines (9) . 1‐Aryl‐2‐amino‐4,5‐dimorpholinoimidazolines lose the amino functionality under mild acidic conditions with formation of 2‐amino‐5‐morpholinoimidazole derivatives (10) whereas 1‐acyl derivatives undergo under the same conditions a ring expansion process leading to pyrimidine derivatives (13) .