2‐Imidazolines. III (1). 1‐Aryl‐ and 1‐acyl‐2‐amino‐(ormethoxy)‐4,5‐diamino‐4,5‐dihydroimidazoles. Synthesis and properties | Zendy

Citerio Luisa | Zendy; Rivera Elisabetta | Zendy; Saccarello Maria Luisa | Zendy; Stradi Riccardo | Zendy; Gioia Bruno | Zendy

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2‐Imidazolines. III (1). 1‐Aryl‐ and 1‐acyl‐2‐amino‐(ormethoxy)‐4,5‐diamino‐4,5‐dihydroimidazoles. Synthesis and properties

Author(s) -

Citerio Luisa,

Rivera Elisabetta,

Saccarello Maria Luisa,

Stradi Riccardo,

Gioia Bruno

Publication year - 1980

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570170120

Subject(s) - chemistry , aryl , pyrimidine , amino acid , salt (chemistry) , ring (chemistry) , medicinal chemistry , stereochemistry , organic chemistry , biochemistry , alkyl

Diimmonium salt (5) reacts with guanidines (6) and o ‐methylisoureas (7) affording 2‐amino‐4,5‐dimorpholinoimidazolines (9) . 1‐Aryl‐2‐amino‐4,5‐dimorpholinoimidazolines lose the amino functionality under mild acidic conditions with formation of 2‐amino‐5‐morpholinoimidazole derivatives (10) whereas 1‐acyl derivatives undergo under the same conditions a ring expansion process leading to pyrimidine derivatives (13) .

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