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Synthesis and Properties of 10‐Benzylaminopterin
Author(s) -
Parham James C.,
Templeton Mary Agnes,
Chello Paul L.,
Sirotnak Francis M.
Publication year - 1979
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570160826
Subject(s) - chemistry , methotrexate , substitution (logic) , inhibitory postsynaptic potential , leukemia , stereochemistry , combinatorial chemistry , medicine , computer science , programming language
Abstract Substitution of a benzyl group for the methyl at N‐10 of Methotrexate caused only a slight decrease in the inhibitory properties of the folate analog against L1210 leukemia in cell culture.