Reexamination of reduced pteridine cofactors behaviour by proton nuclear magnetic resonance spectroscopy and mass spectrometry | Zendy

Hénichart JeanPierre | Zendy; Bernier JeanLuc | Zendy; Dhondt JeanLouis | Zendy; Dautrevaux Michel | Zendy; Biserte Gérard | Zendy

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Reexamination of reduced pteridine cofactors behaviour by proton nuclear magnetic resonance spectroscopy and mass spectrometry

Author(s) -

Hénichart JeanPierre,

Bernier JeanLuc,

Dhondt JeanLouis,

Dautrevaux Michel,

Biserte Gérard

Publication year - 1979

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570160740

Subject(s) - chemistry , autoxidation , mass spectrometry , hydrogen peroxide , cofactor , nuclear magnetic resonance spectroscopy , pteridine , horseradish peroxidase , aqueous solution , spectroscopy , photochemistry , organic chemistry , enzyme , chromatography , physics , quantum mechanics

In aqueous solutions, the autoxidation by air of 2‐amino‐4‐hydroxy‐6,7‐dimethyl‐5,6,7,8‐tetra‐hydropteridine, a hydroxylase cofactor, leads to the corresponding 7,8‐dihydro derivate. Oxidation by hydrogen peroxide and Horseradish peroxidase does not give a stable quinonoid form as previously claimed but affords two metabolic products. Kinetics of the two pathways and structures of the different final compounds were determined by 1 H nmr and mass spectrometry.

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