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Antiulcer agents. 2 . Pyridyl oxime ethers
Author(s) -
Moffett Robert Brace,
Robert André,
Schumann Edward L.,
Paquette Lew A.
Publication year - 1979
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570160734
Subject(s) - oxime , chemistry , hydroxylamine , ketone , aldehyde , organic chemistry , medicinal chemistry , catalysis
A large number of pyridinecarboxaldehyde (and ketone) O ‐substituted oximes were prepared by alkylating the oxime or by treating the parent aldehyde (or ketone) with an O ‐substituted hydroxylamine. Many of these were converted to the N ‐oxide. Screening revealed that many of these oxime ethers were active in preventing gastric ulcers in rats. Data on selected examples is given.