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Synthesis of 5,6‐dihydroxy‐2‐phenyl‐4‐pyrimidinecarboxylic acid, methyl ester, a corrected structure
Author(s) -
Culbertson Townley P.
Publication year - 1979
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570160726
Subject(s) - chemistry , benzamide , dimethyl acetylenedicarboxylate , oxime , acetic acid , adduct , imidazole , pyrolysis , organic chemistry , medicinal chemistry , catalysis , cycloaddition
Pyrolysis of the adduct of benzamide oxime and dimethyl acetylenedicarboxylate leads to 5,6‐dihydroxy‐2‐phenyl‐4‐pyrimidinecarboxylic acid methyl ester ( 4a ) rather than 4,5‐dihydro‐α,4‐dioxo‐2‐phenyl‐1 H ‐imidazole‐5‐acetic acid, methyl ester ( 1 ).
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