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The synthesis of substituted 2‐aminothiazoles
Author(s) -
Lin Yangi,
Seifert C. M.,
Kang S. M.,
Dusza J. P.,
Lang S. A.
Publication year - 1979
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570160718
Subject(s) - chemistry , condensation , halide , thiourea , combinatorial chemistry , stereochemistry , medicinal chemistry , organic chemistry , thermodynamics , physics
The preparation of 4‐ and 5‐acyl‐ and aroyl‐2‐substituted aminothiazoles is described. The condensation of thioureas with acyl halides leading to 4,5‐disubstituted‐2‐aminothiazoles and 7‐(4 H )benzothiazolones is discussed. A discussion of the isolation of various intermediates and the mechanistic pathway is also included. A number of 2‐anilino or 2‐benzyl‐4‐ or 5‐aroylthiazoles possessed moderate oral antitubercolosis activity ( 2 ).