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3‐Substituted imidazo[1,5‐ a ]pyridines
Author(s) -
Albrecht W. L.,
Corona J. A.,
Edwards M. L.
Publication year - 1979
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570160712
Subject(s) - chemistry , triethylamine , phosphorus trichloride , phosphorus , organic chemistry , tar (computing) , medicinal chemistry , programming language , computer science
Cyclization of amides of 2‐aminomethylpyridine gave imidazo[1,5‐ a ]pyridines. In several examples the literature preparation (phosphorus oxychloride) gave extensive tar formation. The use of phosphorus trichloride‐triethylamine (−20°) gave the desired imidazo[1,5‐ a ]pyridines.