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Chemistry of thienopyridines. XXVI. Synthesis of 6‐(γ‐diethylaminopropylamino)thieno[2,3‐ b ]pyridine
Author(s) -
Klemm L. H.,
Bajer Marietta
Publication year - 1979
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570160641
Subject(s) - chemistry , pyridine , fragmentation (computing) , yield (engineering) , rationalization (economics) , medicinal chemistry , philosophy , materials science , epistemology , computer science , metallurgy , operating system
Abstract 6‐(γ‐Diethylaminopropylamino)thieno[2,3‐ b ]pyridine ( 3b ) was obtained (58% yield) from copper‐promoted aminodechlorination of 6‐chlorothieno[2,3‐ b ]pyridine at 168°. A mechanistic rationalization for the reaction and the mass spectral fragmentation pattern for 3b are presented.