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1 H nmr structural analysis of azabicyclospirohydantoins
Author(s) -
Trigo G. G.,
Gálvez E.,
Espada M.,
Bernal C.
Publication year - 1979
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570160529
Subject(s) - chemistry , piperidine , decane , ring (chemistry) , octane , alkyl , carbon 13 nmr , stereochemistry , cyclohexane conformation , nuclear magnetic resonance spectroscopy , crystallography , molecule , organic chemistry , hydrogen bond
The structure and spatial conformation of 3‐alkyl‐3‐azabicyclo[3.2.1]octane‐8‐spiro‐5′‐hydantoins and 8‐alkyl‐8‐azabicyclo[4.3.1]decane‐10‐spiro‐5‐hydantoins has been determined on the basis of the data from 1 H nmr. The chair conformation of the piperidine ring and the presence of only one stereoisomer at the spiro carbon atom are corroborated. All these facts have been confirmed by x‐ray diffraction methods (2).