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Synthesis of 2‐( o ‐chloropheny)‐ and 2‐(2′,6′‐dichlorophenyl)‐4‐formyl‐1,2,3‐triazoles
Author(s) -
Swartz David L.,
El Khadem Hassan S.
Publication year - 1979
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570160515
Subject(s) - chemistry , phenylhydrazine , acetic anhydride , acetic acid , medicinal chemistry , organic chemistry , catalysis
Mesoaldehyde 1,3‐dioxime was treated with either o ‐chlorophenyl‐ or 2,6 dichloro‐phenylhydrazine to give the corresponding 2‐chlorophenylhydrazone. Hydrazones 1a and 1b were treated with acetic anhydride and cyclized to triazoles ( 3a and 6a ) with cesium carbonate. These were then hydrolized to the previously unknown chlorophenyltriazole aldehydes ( 4a and 4b ). They were also converted to a number of acid derivatives, alcohols, and amines.