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The chemistry of 2 H ‐3,1‐benzoxazine‐2,4‐(1 H )dione (isatoic anhydride) 5. Synthesis of the [1]benzopyrano[3,2‐ c ]quinoline ring system
Author(s) -
Coppola Gary M.,
Hardtmann Goetz E.
Publication year - 1979
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570160448
Subject(s) - chemistry , quinoline , tricyclic , ring (chemistry) , organic chemistry , medicinal chemistry , acetic anhydride , catalysis
The reaction of isatoic anhydrides with the anion derived from ethyl o ‐fluorobenzoylacetate to furnish [1]benzopyrano‐[3,2‐ c ]quinolines is described. An analogous reaction with 3‐azaisatoic anhydride furnishes 1b , or with tricyclic anhydride 3 , system 4 is isolated. Spectral data is also discussed.