A convenient and rapid synthesis of potassium penicilliantes using EEDQ | Zendy

Voldeng A. Nelson | Zendy; Fifer Janet T. | Zendy; Brown D. Ray | Zendy

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A convenient and rapid synthesis of potassium penicilliantes using EEDQ

Author(s) -

Voldeng A. Nelson,

Fifer Janet T.,

Brown D. Ray

Publication year - 1979

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570160347

Subject(s) - chemistry , potassium , reagent , salt (chemistry) , steric effects , sodium salt , alkoxy group , sodium , combinatorial chemistry , organic chemistry , inorganic chemistry , alkyl

N ‐ethoxycarbonyl‐2‐ethoxy‐1,2‐dihydroquinoline (EEDQ, 1) has been utilized as a coupling reagent to attach sterically unhindered acids to the potassium salt of 6‐aminopenicillanic acid ( 4 ) at room temperature. The excellent yields and rapidity of the reaction illustrate the convenience of utilizing 1 as the coupling reagent to directly prepare the potassium salt of certain penicillins.

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