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A convenient and rapid synthesis of potassium penicilliantes using EEDQ
Author(s) -
Voldeng A. Nelson,
Fifer Janet T.,
Brown D. Ray
Publication year - 1979
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570160347
Subject(s) - chemistry , potassium , reagent , salt (chemistry) , steric effects , sodium salt , alkoxy group , sodium , combinatorial chemistry , organic chemistry , inorganic chemistry , alkyl
N ‐ethoxycarbonyl‐2‐ethoxy‐1,2‐dihydroquinoline (EEDQ, 1) has been utilized as a coupling reagent to attach sterically unhindered acids to the potassium salt of 6‐aminopenicillanic acid ( 4 ) at room temperature. The excellent yields and rapidity of the reaction illustrate the convenience of utilizing 1 as the coupling reagent to directly prepare the potassium salt of certain penicillins.