Synthesis of 1‐( N ‐piperidinoacetyl)‐4‐arylthiosemicarbazides as possible anticonvulsants

Several 1‐( N ‐piperidinoacetyl)‐4‐arylthiosemicarbazides were synthesized from N ‐piperidinoacetyl hydrazide, which was obtained by the reaction of hydrazine hydrate with ethyl N ‐piperidinoacetate. The anticonvulsant activity of these substituted thiosemicarbazides was reflected by their ability to provide 10–50% protection against pentylenetetrazol‐induced convulsions in mice. All substituted thiosemicarbazides (0.3 m M ) inhibited in vitro monoamine oxidase activity of rat brain homogenates and provided 21–86% protection against hypoosmotic hemolysis at a final concentration of 0.1 m M .