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Synthesis of 1,3‐disubstituted hydantoins as possible anticonvulsants
Author(s) -
Joshi Puran C.,
Parmar Surendra S.,
Rastogi Vinai K.
Publication year - 1979
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570160343
Subject(s) - chemistry , pentylenetetrazol , anticonvulsant , pharmacology , combinatorial chemistry , epilepsy , psychology , medicine , neuroscience
Seven newer 1,3‐disubstituted hydantoins ( 17–23 ) were synthesized from 4‐alkoxyanilines. The anticonvulsant activity of these substituted hydantoins and their precursor carbamides ( 10–16 ) was reflected by their ability to provide 28–80% and 30–70% protection, respectively, against pentylenetetrazol‐induced convulsions in mice. In general, substituted hydantoins possessed greater anticonvulsant activity than their corresponding precursor carbamides.