Synthesis of 1,3‐disubstituted hydantoins as possible anticonvulsants | Zendy

Joshi Puran C. | Zendy; Parmar Surendra S. | Zendy; Rastogi Vinai K. | Zendy

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Synthesis of 1,3‐disubstituted hydantoins as possible anticonvulsants

Author(s) -

Joshi Puran C.,

Parmar Surendra S.,

Rastogi Vinai K.

Publication year - 1979

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570160343

Subject(s) - chemistry , pentylenetetrazol , anticonvulsant , pharmacology , combinatorial chemistry , epilepsy , psychology , medicine , neuroscience

Seven newer 1,3‐disubstituted hydantoins ( 17–23 ) were synthesized from 4‐alkoxyanilines. The anticonvulsant activity of these substituted hydantoins and their precursor carbamides ( 10–16 ) was reflected by their ability to provide 28–80% and 30–70% protection, respectively, against pentylenetetrazol‐induced convulsions in mice. In general, substituted hydantoins possessed greater anticonvulsant activity than their corresponding precursor carbamides.

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