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Studies on the synthesis of analgesics. Part 51 . Synthesis of 4‐(1‐oxo‐2‐isoindolinyl)phenyl derivatives. [Studies on the syntheses of heterocyclic compounds. Part 779 ]
Author(s) -
Kametani Tetsuji,
Kigasawa Kazuo,
Hiiragi Mineharu,
Ishimaru Haruhide,
Nakamura Toshihisa,
Shirayama Keiko
Publication year - 1979
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570160335
Subject(s) - chemistry , phenylbutazone , stereochemistry , combinatorial chemistry , medicinal chemistry , pharmacology , medicine
In order to examine their effect on carrageenin‐induced edema in rats, 4‐(1‐oxo‐2‐isoindolinyl)‐phenyl derivatives were synthesized. 2‐Hydroxy‐3‐[4‐(1‐oxo‐2‐isoindolinyl)phenyl]butyramide was found to be more effective than phenylbutazone.
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