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Synthesis in the diazasteroid group X . A synthesis of 8,12‐diaza‐ D ‐homosteroid
Author(s) -
Yamazaki Takao,
Takahata Hiroki,
Hama Yoko,
Takano Yoshiaki,
Nagata Masanori,
Castle Raymond N.
Publication year - 1979
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570160323
Subject(s) - chemistry , acetic anhydride , acetylation , condensation , tetrahydroisoquinoline , group (periodic table) , catalysis , medicinal chemistry , organic chemistry , stereochemistry , biochemistry , physics , thermodynamics , gene
The condensation of 1‐aminoethyl‐6,7‐dimethoxy‐1,2,3,4‐tetrahydroisoquinoline 1 with 1,2‐cyclohexanedione 2 gave the 8,12‐diaza‐ D ‐homosteroid system 3 , which was reduced with Adams' catalyst followed by acetic anhydride acetylation to afford the 8,12‐diaza‐ D ‐homosteroids 4a,b .