Bis‐aminoquinolines as potential antimalarial agents and a novel fused ring system, pyrano[3,2‐ c :5,6‐ c ′]diquinoline | Zendy

Nasr M. | Zendy; Burckhalter J. H. | Zendy

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Bis‐aminoquinolines as potential antimalarial agents and a novel fused ring system, pyrano[3,2‐ c :5,6‐ c ′]diquinoline

Author(s) -

Nasr M.,

Burckhalter J. H.

Publication year - 1979

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570160317

Subject(s) - quinoline , chemistry , aminoquinolines , ring (chemistry) , medicinal chemistry , antimalarial agent , combinatorial chemistry , stereochemistry , organic chemistry , plasmodium falciparum , malaria , immunology , biology

3,3′(1,3‐Ethyliminodimethylene)bis(4‐hydroxy‐6‐methoxy‐2‐methyl)quinoline ( 2c ) and related compounds were synthesized. 3,3‐Methylenebis(4‐hydroxy‐6‐methoxy‐2‐methyl)quinoline ( 5 ) was prepared and upon treatment with phosphorus oxychloride gave 1,13‐dimethyl‐5,9‐dimethoxy‐14 H ‐pyrano[3,2‐ c :5,6‐ c ′]diquinoIine (6), a novel ring system.

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