Premium
Substituent effects in chemical carcinogenesis: Methyl derivatives of the benzacridines
Author(s) -
Smith Idea A.,
Seybold Paul G.
Publication year - 1979
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570160302
Subject(s) - chemistry , carcinogen , substituent , reactivity (psychology) , computational chemistry , organic chemistry , stereochemistry , medicine , alternative medicine , pathology
An explanation for the different carcinogenic potencies observed among methyl derivatives of the angular benzacridines is given in terms of the tendencies of these compounds to undergo specific metabolic activating reactions analogous to those of polycyclic aromatic hydrocarbons. Theoretical reactivity indices representing these reactions correlate with the carcinogenic activities of these compounds.