Chemical conversion of uridine to 8,5′‐ O ‐cyclo‐3‐deazaguanosine | Zendy

Tanaka Hiromichi | Zendy; Veda Tohru | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Chemical conversion of uridine to 8,5′‐ O ‐cyclo‐3‐deazaguanosine

Author(s) -

Tanaka Hiromichi,

Veda Tohru

Publication year - 1979

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570160247

Subject(s) - chemistry , derivative (finance) , hydroxymethyl , cyanide , uridine , ammonia , nucleoside , imidazole , formaldehyde , carboxylic acid , medicinal chemistry , organic chemistry , stereochemistry , rna , economics , gene , biochemistry , financial economics

Treatment of 1‐(2,3‐ O ‐isopropy lidene‐β‐D‐ribofuranosyl)‐2‐oxo‐4‐imidazoline‐4‐carboxylic acid methyl ester with formaldehyde gave the 5‐hydroxymethyl derivative which, after aeetylalion, gave the 5‐eyanomelhyl derivative by treatment with tetra‐ n ‐butylammonium cyanide. The 2,5′‐ O ‐cyclo derivative of the 5‐cyanomethylimidazole‐4‐carboxylate was converted to the title compound by treatment with ammonia. The present sequence of reactions furnished the chemical conversion of uridine to a 3‐deazaguanosine via the imidazole nucleoside as the intermediate.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research