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Condensed pyridazines. Part II. Synthesis of pyrido[2,3‐ C ] pyridazines
Author(s) -
Maeba Isamu,
Castle Raymond N.
Publication year - 1979
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570160211
Subject(s) - pyridazine , chemistry , nitrene , adduct , cyclohexene , medicinal chemistry , stereochemistry , organic chemistry , catalysis
The synthesis of some pyrido[2,3‐ c ]pyridazines from 5,8‐diehloro‐3‐methyl‐2‐oxo‐2 H ‐pyrano‐[2,3‐ d ]pyridazine (I) is described. Attempted oxidation of 8‐amino‐3‐chloro‐1,6‐dimethyl‐4,7‐dioxo‐1,4,7,8‐tetrahydropyrido[2,3‐ c ]pyridazine (VI) with LTA led only to the deaminated compound VII. Treatment of VI with LTA A in the presence of cyclohexene gave the nitrene adduct XI.