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The kinetics of the reaction of some chloroisoxazolo[4.5‐ c ] and [5,4‐ b ] pyridines with methoxide ion
Author(s) -
Adembri Giorgio,
Ponticelli Alfredo Camparini Fabio,
Tedeschi Piero
Publication year - 1979
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570160111
Subject(s) - chemistry , isoxazole , pyridine , methoxide , reactivity (psychology) , arrhenius equation , ring (chemistry) , kinetics , nucleophilic substitution , medicinal chemistry , nucleophile , ion , kinetic energy , computational chemistry , photochemistry , organic chemistry , catalysis , activation energy , medicine , alternative medicine , physics , pathology , quantum mechanics
Arrhenius parameters were measured for the methoxy‐lechlorination reactions of some chloroderivatives of isoxazolo[4,5‐ c ]‐ and [5,4‐ b ]pyridine. A comparison of these results with the kinetic data for the corresponding chloropyridines shows that fusion of the isoxazole ring with the pyridine ring strongly increases the reactivity of the 4‐ and 6‐positions toward nucleophilic substitution.