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Kinetic evidence for the unusual path in the hydrolysis of amides. p H‐rate profile for N ‐trifluoroacetylindole
Author(s) -
Cipiciani Antonio,
Linda Paolo,
Savelli Gianfranco
Publication year - 1978
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570150869
Subject(s) - chemistry , amide , moiety , hydrolysis , medicinal chemistry , stereochemistry , kinetic energy , organic chemistry , physics , quantum mechanics
The first complete p H‐rate profile (H O ‐4 ÷ p H 12) for an amide is reported. Hydration of carbonyl moiety is suggested to be the first step of the reaction between H O ‐4 ÷ p H 6.
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