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Reaction of diethyl acetonedicarboxylate with nitrosyl chloride
Author(s) -
Silverman Richard B.
Publication year - 1978
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570150860
Subject(s) - chemistry , yield (engineering) , chloride , medicinal chemistry , organic chemistry , thermodynamics , physics
The reaction of diethyl acetonedicarboxylate with greater than two equivalents of nitrosyl chloride or the reaction of diethyl isonitrosoacetonedicarboxylate with one equivalent of nitrosyl chloride gave diethyl 4‐hydroxyisoxazole‐3,5‐dicarboxylate in quantitative yield. Mechanistic possibilities are discussed.