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Direct sulfhydrolysis of cyclic AMP: A one‐step synthesis of the cyclic ribonucleotide of 6‐mercaptopurine
Author(s) -
Meyer Rich B.,
Stone Thomas E.,
Heinzel Frederick P.
Publication year - 1978
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570150856
Subject(s) - chemistry , ribonucleotide , mercaptopurine , cyclic gmp , stereochemistry , combinatorial chemistry , nucleotide , organic chemistry , biochemistry , pharmacology , enzyme , medicine , gene
Treatment of adenosine cyclic 3′,5′‐phosphate with liquid H 2 S in aqueous pyridine provided a convenient, one‐step synthesis of 9‐β‐D‐ribofuranosylpurine‐6(1 H ) thione cyclic 3′,5′‐phosphate.
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