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4‐Amino‐6‐hydroxy‐1 H ‐pyrrolo[3,2‐ c ] pyridine (3,7‐dideazaisoguanine)
Author(s) -
Schneller S. W.,
Hosmane R. S.
Publication year - 1978
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570150853
Subject(s) - chemistry , pyridine , sodium carbonate , aqueous solution , acetic acid , ring (chemistry) , medicinal chemistry , stereochemistry , sodium , organic chemistry
The preparation of 4‐amino‐6‐hydroxy‐1 H ‐pyrrolo[3,2‐ c ]pyridine (3,7‐dideazaisoguanine) ( 1 ) in five steps from 1 H ‐pyrrolo[3,2‐ c ]pyridin‐4,6(5 H ,7 H ) dione (3,7‐dideazaxanthine) ( 2 ) is described. Furthermore, prolonged treatment of 1 with 10% aqueous sodium carbonate solution is reported to lead to ring opening of the pyridine of 1 resulting in 3‐carboxamidopyrrole‐2‐acetic acid ( 3 ).