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Acylation of heteroaromatic amines . Perbenzoylation of diaminopyridazines
Author(s) -
Suzuki Toshinobu,
Katou Nobuhiro,
Mitsuhashi Keiryo
Publication year - 1978
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570150840
Subject(s) - pyridazine , chemistry , triethylamine , acylation , hydrazine (antidepressant) , yield (engineering) , benzoyl chloride , medicinal chemistry , organic chemistry , catalysis , chromatography , materials science , metallurgy
Some diaminopyridazines such as 4,7‐diaminoimidazo[4,5‐ d ]pyridazine, 1‐methyl‐4,7‐diaminoimidazo[4,5‐ d ]pyridazine, 5,8‐diaminopyrazino[2,3‐ d ]pyridazine, 2,3‐dimethyl‐5,8‐diaminopyrazino[2,3‐ d ]pyridazine and 1,4‐diaminophthalazine, all of which were prepared by the reaction of hydrazine with the respective vic ‐dicyanide as starting material, were reacted with benzoyl chloride in the presence of triethylamine, giving novel perbenzoylated derivatives in good yield. A dibenzoylation mechanism of the amino group has been proposed.