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The use of α‐(aryl)‐4‐morpholineacetonitriles (masked acyl anion equivalents) in 1,4‐additions to α,β‐unsaturated esters and nitriles. A versatile synthetic route to 6‐aryl‐3(2 H ) pyridazinones
Author(s) -
Albright J. D.,
Mcevoy F. J.,
Moran Daniel B.
Publication year - 1978
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570150601
Subject(s) - chemistry , acrylonitrile , aryl , ethyl acrylate , acrylate , organic chemistry , methyl acrylate , medicinal chemistry , alkyl , polymer , monomer , copolymer
Abstract The use of α‐(substituted‐phenyl)‐4‐morpholineacetonitriles in 1,4‐additions to ethyl acrylate, ethyl crotonate, methyl α‐methylacrylate, acrylonitrile, methylacrylonitrile, crotononitrile and cinnamonitrile was studied. A convenient route to 6‐aryl‐4,5‐dihydro‐3(2 H ) pyridazinones from aryl aldehydes and heterocyclic aldehydes was developed.