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Preparation of some tricyclic fused ring iminopyrido[3,2‐ e ]pyrimidines
Author(s) -
Kwok Russell
Publication year - 1978
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570150531
Subject(s) - chemistry , tricyclic , ethylenediamine , ring (chemistry) , cyanogen bromide , derivative (finance) , bromide , medicinal chemistry , stereochemistry , combinatorial chemistry , organic chemistry , biochemistry , economics , financial economics , peptide sequence , gene
Abstract The preparation of a number of tricyclic fused ring iminopyrido[3,2‐ e ]pyrimidines is described. Treatment of 2‐chloronicotinonitrile with primary amines afforded the corresponding 2‐amino derivative which was condensed with ethylenediamine or higher congeners to give substituted cyclic amidines. The latter on treatment with cyanogen bromide gave the desired imino‐pyrido[3,2‐ e ]pyrimidines. The preparation of diaminopyrido[2,3‐ d ]pyrimidines and tricyclic quinazolines by related procedures is discussed.