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Studies on 1 H ‐ and 2 H ‐ N ‐alkylpyrazolo[3,4‐ d ]pyridazin‐4(5 H )ones
Author(s) -
Gelin Suzanne,
Hartmann Daniel
Publication year - 1978
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570150520
Subject(s) - chemistry , methylhydrazine , ring (chemistry) , hydrazine (antidepressant) , medicinal chemistry , closure (psychology) , alkyl , stereochemistry , organic chemistry , phenylhydrazine , chromatography , economics , market economy
A series of two N ‐substituted‐3(5)acyl4‐ethoxycarbonyl‐5(3)substituted isomeric pyrazoles underwent ring closure with hydrazine and methylhydrazine to give the new anticipated N (1)‐or N (2)alkyl‐3,7‐disubstituted pyrazolopyridazin‐4(5 H )ones. The purpose of this study was to determine distinguishing criteria between the two isomers. From the comparative 1 H‐ and 1 3 C‐nmr spectra, sufficiently significant differences were observed. Uv and ir spectra showed no significant differences.