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New syntheses of pyrimido[4,5‐c]pyridazines related to fervenulin
Author(s) -
Senga Keitaro,
Sato Junko,
Kanamori Yukako,
Ichiba Misuzu,
Nishigaki Sadao,
Noguchi Mitsukò,
Yoneda Fumio
Publication year - 1978
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570150515
Subject(s) - chemistry , phenacyl , formamide , uracil , pyridazine , medicinal chemistry , dimethyl formamide , organic chemistry , stereochemistry , dna , biochemistry , solvent
Pyrimido[4,5‐c]pyridazines related to an antibiotic fervenulin were prepared by two routes: one involving the reaction of 6‐hydrazino‐1,3‐dimethyl(or 3‐methyl)uracil with phenacyl bromides, and the other involving the reaction of 6‐benzylidenehydrazino‐1,3‐dimethyluracils with dimethyl‐formamide dimethylacetal.