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Reactions of acetylenic ketones with methyl α‐naphthylacetate. A synthesis of l‐amino‐2‐pyridone derivatives
Author(s) -
AlFarkh Y. A.,
AlHajjar F. H.,
ElRayyes N. R.,
Hamoud H. S.
Publication year - 1978
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570150510
Subject(s) - chemistry , hydrazine (antidepressant) , sodium methoxide , hydrate , ethanol , medicinal chemistry , aryl , organic chemistry , methanol , alkyl , chromatography
Reactions of acetylenic ketones (Ia‐f) with methyl α‐naphthylacetate in the presence of sodium methoxide gave the corresponding 6‐aryl‐3‐α‐naphthyl‐4‐phenyl‐2‐pyrones (IIa‐f) which upon refluxing with hydrazine hydrate in ethanol gave the corresponding 1‐amino‐2‐pyridone derivatives (VIa‐f). The structure of the products was established by chemical and spectroscopic evidence.