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The knoevenagel condensation of ethyl acylpyruvates
Author(s) -
Kurihara Takushi,
Sakamoto Yasuhiko,
Kobayashi Toshio,
Mori Masanobu
Publication year - 1978
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570150506
Subject(s) - knoevenagel condensation , chemistry , piperidine , yield (engineering) , aldehyde , organic chemistry , ethyl cyanoacetate , condensation , benzaldehyde , medicinal chemistry , malononitrile , catalysis , materials science , physics , metallurgy , thermodynamics
Extensive studies of the Knoevenagel condensation of aromatic aldehydes and active methyl‐lene compounds have been reported (2). In 1894, Knoevenagel reported (3) the reaction of benz‐aldehyde with ethyl benzoylpyruvate in the presence of piperidine to give ehtyl benzyl‐(bis‐benzoyl)pyruvate, m.p. 162°, but no yield of the product was reported. This paper deals with the interesting results of the reactions of ethyl acetylpyruvate ( 2 ) ( 4 ) and ethyl benzoylpyruvate ( 3 ) (5) with some aromatic aldehydes ( 1a‐f ).