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A general method for the preparation of N ‐monosubstituted‐3‐isothiazolamines
Author(s) -
Rokach J.,
Hamel P.
Publication year - 1978
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570150439
Subject(s) - chemistry , yield (engineering) , ring (chemistry) , alkyl , ammonia , medicinal chemistry , halo , combinatorial chemistry , organic chemistry , materials science , physics , quantum mechanics , galaxy , metallurgy
We describe here a novel and general high yield method for the synthesis of 3‐alkyl and arylaminoisothiazoles, a previously unknown group of isothiazoles, by the reaction of ammonia with 3‐halo‐2‐alkylisothiazolium salts. The mechanism of the reaction probably involves a ring opening followed by a recyclization to the title compounds.