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Synthesis of l‐( N ‐acelylpiperidino)‐4‐aryl semicarbazides as possible anticonvulsants
Author(s) -
Misra R. S.,
Dwivedi C.,
Parmar S. S.,
Singh S. P.
Publication year - 1978
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570150432
Subject(s) - chemistry , hydrazide , hydrazine (antidepressant) , pentylenetetrazol , hydrate , monoamine oxidase , aryl , anticonvulsant , pharmacology , stereochemistry , organic chemistry , chromatography , enzyme , epilepsy , medicine , alkyl , neuroscience , biology
Six 1‐( N ‐acetylpiperidino)‐4‐aryl semicarbazides were synthesized from ethyl‐ N ‐piperidino‐aeetatc which on treatment with hydrazine hydrate was converted into N ‐piperidinoacethydrazide. The resulting hydrazide on treatment with the appropriate arylisoeyanales formed l ‐( N ‐acelyl‐piperidino)‐4‐aryl semicarbazides. Amongst these piperidinosemicarbazides, three compound possessed low anticonvulsanl activity and provided 20‐40% protection against pentylenetetrazol‐induced convulsions in mice. All piperidino semicarbazides (0.1 m M ) possessed antihemolytic activity (13‐35%) and caused 40‐72% inhibition of monoamine oxidase activity of rat brain homogenates at a final concentration of 0.3 m M .