Synthesis of l‐( N ‐acelylpiperidino)‐4‐aryl semicarbazides as possible anticonvulsants

Six 1‐( N ‐acetylpiperidino)‐4‐aryl semicarbazides were synthesized from ethyl‐ N ‐piperidino‐aeetatc which on treatment with hydrazine hydrate was converted into N ‐piperidinoacethydrazide. The resulting hydrazide on treatment with the appropriate arylisoeyanales formed l ‐( N ‐acelyl‐piperidino)‐4‐aryl semicarbazides. Amongst these piperidinosemicarbazides, three compound possessed low anticonvulsanl activity and provided 20‐40% protection against pentylenetetrazol‐induced convulsions in mice. All piperidino semicarbazides (0.1 m M ) possessed antihemolytic activity (13‐35%) and caused 40‐72% inhibition of monoamine oxidase activity of rat brain homogenates at a final concentration of 0.3 m M .