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The synthesis and ring opening of N ‐substituted‐2‐oxo‐6‐azaspiro[2,5] octanes
Author(s) -
Popp Frank D.,
Watts Raymond F.
Publication year - 1978
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570150430
Subject(s) - chemistry , aluminum hydride , ring (chemistry) , piperidine , lithium (medication) , iodide , chloride , lithium iodide , medicinal chemistry , hydride , organic chemistry , ion , medicine , hydrogen , electrode , electrolyte , endocrinology , methoxide
N ‐Substituted‐4‐piperidones have been reacted with trimethyl sulfoxonium iodide to give the title compounds. These undergo ring opening with lithium aluminum hydride‐aluminum chloride to give piperidine‐4‐methanols which were converted to the chloromethylpiperidines.