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Quinazolincs and 1,4‐benzodiazepines. LXXXVI . The synthesis of imidazothienodiazepines and imidazopyrazolodiazepines
Author(s) -
Fryer R. Ian,
Earley James V.,
Walser Armin
Publication year - 1978
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570150419
Subject(s) - diazepine , chemistry , ring (chemistry) , tricyclic , d 1 , stereochemistry , bicyclic molecule , medicinal chemistry , organic chemistry , receptor , biochemistry
The thieno[3,2‐ e ][1,4]diazepin‐2‐one ( 1a ), the thieno[2,3‐ e ] [ 1,4] diazepin‐2‐one ( 1b ), the pyrazolo[3,4‐ e ][1,4]diazepin‐2‐one ( 1c ) and a chloro analog of 1b , compound 1 d , were each converted to derivatives of the novel tricyclic ring systems 4 H ‐imidazo[1,5‐ a ]thieno[2,3‐ f ] [1,4]‐diazepine, 4 H imidazo[1,5 a ]thieno[2,3 f ][1,4]diazepine and 4 H ‐imidazo[ 1,5‐a]pyrazolo[4,3‐ f ]‐[1,4]diazepine. Depending on the substituents desired on the imidazo ring, two different synthetic pathways were employed.