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An improved synthesis of gliamilide®, a high‐potency sulfamylurea hypoglycemic agent
Author(s) -
Kuhla Donald E.,
Sarges Reinhard,
Barth Wayne E.
Publication year - 1978
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570150408
Subject(s) - chemistry , moiety , ring (chemistry) , potency , pyridine , hydrochloride , nicotinamide , alkyl , salt (chemistry) , stereochemistry , combinatorial chemistry , medicinal chemistry , organic chemistry , biochemistry , in vitro , enzyme
An efficient synthesis of the sulfamylurea, Gliamilide ® , is described, which involves as a key feature the selective reduction of the more basic alkyl‐substituted pyridine ring in the mono‐hydrochloride salt of dipyridyl compound 11 to form 12 without affecting the 2‐methoxy‐nicotinamide moiety.