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Linearly fused isoquinolines. Part II . The synthesis of the s ‐triazolo[4,3‐ b ]isoquinoline system
Author(s) -
Hajós Gy.,
Messmer A.
Publication year - 1978
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570150318
Subject(s) - isoquinoline , chemistry , ring (chemistry) , salt (chemistry) , oxide , derivative (finance) , perchlorate , combinatorial chemistry , stereochemistry , medicinal chemistry , organic chemistry , ion , financial economics , economics
3‐Hydrazinoisoquinoline ( 2 ) was synthesized via its N ‐oxide derivative by removal of the N ‐oxide funçtion with titanium trichloride. Acylation of the hydrazino compound ( 2 ) led to suitable starting materials ( 4 and 6 ) for cyclization to the novel, linearly fused ring system: tri‐azolo[4,3‐ b ]isoquinoline, which was more stable in the form of its perchlorate salt. The structure of the first representatives of the new ring system was proved by ir, nmr and ms spectroscopy.