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Thiocyanation of indoles
Author(s) -
Tamura Yasumitsu,
Kwon Sundo,
Chun Moon Woo,
Ikeda Masazumi
Publication year - 1978
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570150312
Subject(s) - chemistry , indole test , acetic acid , organic chemistry , medicinal chemistry , stereochemistry
Treatment of indole, 2‐phenylindole, 2‐methylindole, and ethyl indole‐2‐carboxylate with thiocyanogen in acetic acid at 0° afforded the corresponding 3‐thiocyanatoindoles in quantitative yields, whereas similar treatment of 3‐methyl‐2‐phenylindoles and 2,3‐diphenylindoles gave the corresponding 6‐thiocyanatoindoles in high yields.