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Pyrazolo[3,4‐ b ]pyridines. I. Xanthine and isoguanine analogs derived from 1‐methylpyrazolo[3,4‐ b ]pyridine
Author(s) -
Schneller S. W.,
Moore D. R.
Publication year - 1978
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570150229
Subject(s) - chemistry , pyridine , xanthine , nitrile , stereochemistry , medicinal chemistry , organic chemistry , enzyme
The synthesis of 4,6‐dihydroxy‐l‐methylpyrazolo[3,4‐ b Jpyridine ( 2 ) and 4‐amino‐6‐hydroxy‐1‐methylpyrazolo[3,4‐ b ] pyridine ( 3 ) as analogs of xanthine and isoguanine has been accomplished from ethyl 5‐amino‐1‐methylpyrazole‐4‐carboxylate ( 4 ) and 5‐amino‐1‐methylpyrazole‐4‐carbo‐nitrile ( 6 ), respectively.