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Potential causal prophylactic antimalarial agents. Synthesis of quinoxaline, benzimidazole, and alkoxybenzene derivatives containing a novoldiamine moiety
Author(s) -
Yan S. J.,
Burton William H.,
Chien PingLu,
Cheng C. C.
Publication year - 1978
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570150223
Subject(s) - benzimidazole , quinoxaline , chemistry , moiety , combinatorial chemistry , ring (chemistry) , stereochemistry , organic chemistry
Several quinoxaline, benzimidazole, and alkoxybenzene derivatives containing the novoldiamine function, either as a side chain or incorporated as a ring constituent, were synthesized as potential causal prophylactic antimalarial agents. 1‐(5‐Dimethylamino‐2‐pentyl)‐5‐methoxy‐benzimidazole ( 2a ) was shown to have the desired prophylactic activity in the preliminary sporozoitc‐indueed Plasmodium gallinaceum test.