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Syntheses of pyrimidine and purine analogs derived from 1,2,6‐thiadiazine 1,1‐dioxide
Author(s) -
Ochoa C.,
Stud M.
Publication year - 1978
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570150208
Subject(s) - chemistry , sulfamide , pyrimidine , medicinal chemistry , stereochemistry , organic chemistry
5‐Amino‐3‐oxo‐2 H , 4 H ‐1,2,6‐thiadiazine 1,1‐dioxide and the monopotassium salt of 3,5‐dioxo‐2 H , 4 H ,6 H ‐1,2,6‐thiadiazine 1,1‐dioxide was obtained by condensation of sulfamide and ethyl cyanacetate and diethyl malonate, respectively. 7‐Oxo‐1 H ,4 H ,6 H ‐imidazo[2,3‐ c ]‐1,2,6‐thia‐diazine 5,5‐dioxide was prepared by a multi‐step reaction sequence from 5‐amino‐3‐oxo‐2 H , 4 H ‐1,2,6‐thiadiazine 1,1‐dioxide.

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