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Quinazolines and 1,4‐benzodiazepines LXXXII . Reaction of 2‐hydrazino‐benzodiazepines with 1,3‐diearbonyl compounds
Author(s) -
Walser Armin,
Zenchoff Gladys
Publication year - 1978
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570150136
Subject(s) - chemistry , benzodiazepine , hydrazone , cyclohexane , ring (chemistry) , medicinal chemistry , organic chemistry , biochemistry , receptor
The 2‐hydrazinobenzodiazepines 1 were reacted with acelylacelone to form the hydroxy‐pyrazolines 2 which were converted to the triazolobenzodiazcpines 6 and the 2‐pyrazolyl‐benzodiazepine 4 . Ring cleavage of the hydrazone 8 obtained from cyclohexane‐1,3‐dione and 1a led similarly to the 1‐(4‐oxopentyl)triazolol)enzodiazepine 12 .
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