Reactions of 2 ‐dichloromethylbenzimidazole with certain primary amines | Zendy

Pascal Robert A. | Zendy; Jungk Steven | Zendy; Risinger G. E. | Zendy

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Reactions of 2 ‐dichloromethylbenzimidazole with certain primary amines

Author(s) -

Pascal Robert A.,

Jungk Steven,

Risinger G. E.

Publication year - 1978

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570150131

Subject(s) - chemistry , benzimidazole , primary (astronomy) , alkali metal , dimer , diol , medicinal chemistry , organic chemistry , combinatorial chemistry , physics , astronomy

An investigation of the reactions of 2,2‐dichloromethylbenzimidazole with primary amines has led to the synthesis of 2( N ‐ t ‐butylformimidoyl)benzimidazole, 2‐ N ‐(2‐phenylethyl)formimdoylbenzimidazole, and 1‐(ethoxyearbonylmethyl)‐2‐( N ‐ t ‐butylformimidoyl)benzimidazole. Under mild alkali conditions, 2,2‐dichloromethylbenzimidazole was rapidly converted into a dimer, namely, 6 H ,13 H ‐pyrazino[1,2‐ a :4,5‐ a ']bisbenzimidazole‐6,13‐diol.

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