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Synthesis of 5‐methylfuro[3,2‐ b ]pyridine‐2‐carboxylic acid
Author(s) -
Weis C. D.
Publication year - 1978
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570150106
Subject(s) - chemistry , saponification , hydrochloric acid , hydrochloride , pyridine , aldehyde , carboxylic acid , organic chemistry , condensation , manganese , medicinal chemistry , catalysis , physics , thermodynamics
Oxidation of 3‐hydroxy‐6‐methyl‐2‐hydroxymethylpyridine with manganese dioxide yielded the corresponding aldehyde, the condensation of which with diethyl bromomalonate furnished hydroxydihydrofuro[3,2‐ b ]pyridinediearboxylie acid ester. Saponification of the diester with concentrated hydrochloric acid afforded the hydrochloride of 5‐methylfuro[3,2‐ b ]pyrjdine car‐boxylic acid.
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